Watch as Gleevec, an anti-cancer drug, inhibits the action of BCR-ABL, a mutated kinase responsible for the overproduction of blood cells in chronic myeloid leukemia. Gleevec targets an ATP-binding site on BCR-ABL, preventing the binding of ATP and deactivating the enzyme, limiting the enzyme’s ability to phosphorylate other molecules and propagate a signal – and ultimately, reducing blood cell division and cancer. http://bit.ly/gleevecBI | BioInteractive
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