TOP1 - Wikipedia
It is a DNA topoisomerase, an enzyme that catalyzes the transient breaking and rejoining of a single strand of DNA. This gene encodes a DNA topoisomerase, an enzyme that controls and alters the …
TOP1 Gene - GeneCards | TOP1 Protein | TOP1 Antibody
Jan 15, 2026 · TOP1 (DNA Topoisomerase I) is a Protein Coding gene. Diseases associated with TOP1 include Hematologic Cancer and Spinocerebellar Ataxia, Autosomal Recessive, With Axonal …
TOP 1 Oil | Premium Lubricants & Additives
From deserts to remote mountain roads, TOP 1 users push boundaries and chase adventure across the globe. These are the stories of riders, racers, and explorers who trust TOPTECH-powered lubricants …
RNA interacts with topoisomerase I to adjust DNA topology
Aug 21, 2024 · Topoisomerase I (TOP1) is an essential enzyme that relaxes DNA to prevent and dissipate torsional stress during transcription. However, the mechanisms underlying the regulation of …
Topoisomerase I in Human Disease Pathogenesis and Treatments
May 12, 2016 · Mammalian topoisomerase 1 (TOP1) is an essential enzyme for normal development. TOP1 relaxes supercoiled DNA to remove helical constraints that can otherwise hinder DNA …
What are TOP1 inhibitors and how do they work?
Jun 21, 2024 · Topoisomerase I (TOP1) inhibitors represent a significant class of anticancer agents, playing a vital role in the treatment of various malignancies. By targeting the enzyme topoisomerase …
Top1-PARP1 association and beyond: from DNA topology to break …
One of the most common forms of DNA damage that arise in cells are single-strand breaks (SSBs). The SSBs can occur from the abortive activity of DNA topoisomerase 1 (Top1), due to the covalent …
Topoisomerase I inhibitors: Challenges, progress and the road ahead
Jun 5, 2022 · Topoisomerase IB (Top1), a subcategory of DNA topoisomerase enzymes is expressed much higher in several tumor cells. Therefore, modulating the activity of Top1 in tumor cells to …
Topoisomerase 1 inhibition suppresses inflammatory genes and …
We identified topoisomerase 1 (Top1) as a positive regulator of RNA polymerase II transcriptional activity at pathogen-induced genes. Depletion or chemical inhibition of Top1 suppresses the host …
Project 1: Next-Generation TOP1 Inhibition To Treat Ovarian Cancer
In this research project, investigators in the Mayo Clinic Ovarian Cancer SPORE are assessing DNA topoisomerase 1 (TOP1) inhibitors to treat ovarian cancer.