The rap sheet for β-CTF is growing longer. The C-terminal fragment, produced when β-secretase cleaves APP, binds to—and blocks assembly of—vacuolar ATPase, a proton pump that fuels acidification of ...
Experimental electron micrograph of purified synaptic vesicles (upper). Synaptic vesicles automatically identified in the image with a new computer program are highlighted with different colours and ...
Lysosomes require tight regulation of their pH to degrade their contents. Researchers know that V-ATPase pumps protons into these little digestive sacs, but what protein shuttles the ions back out?
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