If you are anything like us, whenever you plan a journey, you spend a remarkable amount of time thinking about the start and the middle. Is everything packed? What time should we leave? Will there be ...

Accurate duplication of the genome is fundamental to cellular viability and prevention of disease. Replicative DNA polymerases achieve high fidelity through three interconnected mechanisms: intrinsic ...

Bacterial DNA replication is a highly coordinated process that ensures faithful genome duplication and cell division. Replication initiates at a single chromosomal origin (oriC) where multiple copies ...

Red arrows indicate the DNA repair pathways that are known to aid bacterial survival as persisters and gamblers in the presence of fluoroquinolones. Blue color arrow indicates downregulation, while ...

When bacteria cells replicate, they do so a little differently than human cells do. They don't undergo mitosis, a splitting that involves construction of spindles to carefully separate the DNA after ...

In the study of bacteria, a longstanding dogma has held that two molecular machines—RNA polymerase, which leads the way in ...

Structural biologists at the University of Wisconsin-Madison today published cryo-electron microscopy structures of the complete bacterial DNA replication restart complex — a molecular machine that ...

Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...

Transposons are critical drivers of bacterial evolution that have been studied for many decades and have been the subject of Nobel Prize winning research. Now, researchers from Cornell University have ...