(A) Schematic design of an experiment for identifying metastasis-related genes using a CRISPR/Cas9 library in an orthotopic murine model of OC. (B) The bioluminescence signals and quantifications of ...

The Nature Index 2025 Research Leaders — previously known as Annual Tables — reveal the leading institutions and countries/territories in the natural and health sciences, according to their output in ...

The immune system plays a crucial role in fighting tumours and metastases. Consequently, it is decisive to conduct cancer research in mouse models with an immune system that is as natural as possible ...

A team of scientists has harnessed CRISPR technology to identify a protein that helps cancers spread to bone tissue, opening the door for potential therapies to prevent the common and painful disease ...

Fred Hutch researchers invent a CRISPR screening method to understand RNA-binding proteins often mutated in cancer and other diseases In biology’s standard tale of two acids — deoxyribonucleic (DNA) ...

Revvity's Dharmacon All-in-one lentiviral platform has expanded to include whole-genome library options for CRISPR knockout (CRISPRko), CRISPR interference (CRISPRi), and CRISPR activation (CRISPRa).

Targeting the intracellular immune checkpoint CISH with CRISPR-Cas9-edited tumor-infiltrating lymphocytes (TILs) may be effective for patients with metastatic colorectal cancer (CRC) refractory to ...

A gene called KLF5 may be a key force behind the spread of pancreatic cancer—but not in the way scientists expected. Rather than mutating DNA, it rewires how genes are turned on and off, helping ...

Recently, scientists have been able to explore gene circuitry in individual cells using methods that suppress particular ...

New research from Memorial Sloan Kettering Cancer Center (MSK) uncovers new details of the immune response against leptomeningeal metastasis; develops a grading system to assess the risk of developing ...